鍖椾含闆�鏂戜笓绉戝尰闄? http://pf.39.net/bdfyy/dbfzl/210304/8713966.htmlTODAY今日发布JACCCardiovascIntervDec23,:12(24),-今日发布29篇JACCDec24,:74(25),-今日发布18篇HeartFailRevEarlyRecent,Dec17,今日发布01篇JThrombThrombolysisEarlyRecent,Dec17,今日发布02篇CARDIOVASCRESJan01,:(1)今日发布31篇CardiovascDrugsTherEarlyRecent,Dec18,今日发布01篇PediatricCardiologyEarlyRecent,Dec18,今日发布01篇RECOMMEND推荐阅读01慢性心力衰竭的高敏C反应蛋白：患者特征、表型和死亡方式CARDIOVASCRESPierpaoloPellicori,JufenZhang,etc.2小时前等16用户推荐阅读本文Plasmaconcentrationsofhigh-sensitivityC-reactiveprotein(hsCRP)areoftenraisedinchronicheartfailure(CHF)andmightindicateinflammatoryprocessesthatcouldbeatherapeutictarget.WeaimedtostudytheassociationsbetweenhsCRP,modeandcauseofdeathinpatientswithCHF.慢性心力衰竭（CHF）患者血浆高敏C反应蛋白（hsCRP）浓度升高，提示炎症过程可能是治疗的靶点。本研究旨在探讨慢性心力衰竭（CHF）患者hsCRP、死亡方式与死因的关系。Weenrolledpatientsreferredtoaheartfailureclinicservingalocalpopulation.CHFwasdefinedasrelevantsymptomsorsignswitheitherareducedleftventricularejectionfraction40%orraisedplasmaconcentrationsofamino-terminalpro-Btypenatriureticpeptide(NT-proBNP?pg/mL).Themedian[interquartilerange(IQR)]plasmahsCRPforpatientsdiagnosedwithCHF(n?=?)was3.9(1.6–8.5)mg/Land2.7(1.3–5.1)mg/Lforthosewhowerenot(n?=?;P??0.).PatientswithhsCRP≥10?mg/L(N?=?;22%)wereolderandmorecongestedthanthosewithhsCRP2?mg/L(N?=?,30%).Duringamedianfollow-upof53(IQR28–93)months,(48%)patientswithCHFdied.HigherplasmahsCRPwasassociatedwithgreatermortality,independentofage,symptomseverity,creatinine,andNT-proBNP.ComparingahsCRP≥10?mg/Lto2?mg/L,thehazardratioforall-causemortalitywas2.49(95%confidenceinterval2.19–2.84;P??0.),forcardiovascular(CV)mortalitywas2.26(1.91–2.68;P??0.),andfornon-CVmortalitywas2.96(2.40–3.65;P??0.).我们登记了名患者，他们被转介到一家为当地居民服务的心力衰竭诊所。CHF是指左室射血分数低于40%或血浆氨基末端前B型利钠肽浓度升高（NT-proBNP?pg/mL）的相关症状或体征。诊断为CHF（n?=?）的患者血浆hsCRP中位数[四分位范围（IQR）]3.9（1.6–8.5）mg/L，而诊断为CHF（n?=?；P?0.）的患者血浆hsCRP中位数为2.7（1.3–5.1）mg/L。hsCRP≥10?mg/L（N?=?；22%）的患者比hsCRP2?mg/L（N?=?，30%）的患者年龄大，充血程度高。在53个月（28-93伊拉克第纳尔）的中位随访中，名（48%）CHF患者死亡。血浆hsCRP升高与死亡率升高相关，与年龄、症状严重程度、肌酐和NT-proBNP无关。将hsCRP≥10?mg/L与2?mg/L比较，全因死亡率的危险比为2.49（95%可信区间2.19-2.84；P?0.），心血管（CV）死亡率为2.26（1.91-2.68；P?0.），非CV死亡率为2.96（2.40-3.65；P?0.）。InpatientswithCHF,araisedplasmahsCRPisassociatedwithmorecongestionandaworseprognosis.Theproportionofdeathsthatarenon-CValsoincreaseswithhigherhsCRP.在CHF患者中，血浆hsCRP升高与充血加重和预后恶化有关。随着hsCRP的升高，非心血管疾病的死亡比例也增加。扫描
